ABSTRACT
Tranexamic acid (TXA) is a commonly used antifibrinolytic drug during surgical procedures to reduce blood loss. An Inadvertent intrathecal injection of TXAmay lead to serious side effects including seizures and ventricular fibrillation with reported fatalities. We report a case of an inadvertentintrathecal injection of TXAwhich occurred as a result of similarities in appearance between TXAand heavy bupivacaine ampoules. The patient had subarachnoid lavage after experiencing back pain, systemic hypertension followed by generalized tonic clonic seizures
Subject(s)
Humans , Injections, Spinal , Back Pain , Tranexamic Acid , Intracranial Pressure , Therapeutic IrrigationABSTRACT
Le but de l'etude est d'identifier les facteurs precoces; permettant de porter un diagnostic d'hypertension intracranienne chez les traumatises craniens graves (GCS? 8). -675 patients craniens graves (GCS? 8) ont ete inclus dans une etude retrospective de donnees recueillies prospectivement; -Differents facteurs demographiques - cliniques - tomodensitometriques - therapeutiques ont ete analyses; -Leur correlation avec la survenue d'une hypertension intracranienne a ete analysee selon une approche statistique multivariee. En analyse multivariee; des sillons diminues ou effaces; des ventricules diminues ou fentes; des citernes diminuees ou absentes sont significativement correles a la survenue d'une hypertension intracranienne. A l'inverse le traitement neurochirurgical; apparait comme un facteur contribuant a faire diminuer le risque de developper une HTIC
Subject(s)
Craniocerebral Trauma , Craniocerebral Trauma/diagnosis , Intracranial Pressure , TherapeuticsABSTRACT
A rise in the intracranial pressure can result from a variety of conditions both traumatic and non-traumatic. Whereas in many of the cases the mechanisms leading to a rise in ICP are obvious; in a few such as endocrine causes and benign intracranial hypertension (BIH); the mechanisms are not known